Th22, Th17.1, Tc17, Tfh and NKTfh lymphocytes in pathogenesis of multiple sclerosis
نویسندگان
چکیده
منابع مشابه
P136: The Role of Th1 Lymphocytes in the Pathogenesis of Multiple Sclerosis (MS)
Th1 lymphocytes produce cytokines such as IL-2, IFN-γ, and TNF-α, TNF-β and GM-CSF and play an important role in the increase of delaying sensitivity and defense against intracellular pathogens. IFN-γ is the most important Th1 cell cytokine that induces the production of IgG, activation of macrophages,enhancing phagocytosis, and also increasing MHC class I and class II mo...
متن کاملP170: The Role of Th1 Lymphocytes in The Pathogenesis of Multiple Sclerosis (MS)
Th1 lymphocytes produce cytokines such as IL-2, IFN-γ, and TNF-α, TNF-β and GM-CSF. IFN-γ is the most important Th1 cell cytokine that induces the production of IgG, activation of macrophages, enhancing phagocytosis, and also increasing MHC class I and class II molecules. Increasing serum level of Th1 cytokines have also been observed in MS patients. It has also been prov...
متن کاملPathogenesis of multiple sclerosis.
PURPOSE OF REVIEW The aim of this article is to describe recent observations regarding the basis for the initiation and disease evolution of multiple sclerosis. RECENT FINDINGS A current debate is where and what initiates the neuroinflammatory reaction that characterizes the acute multiple sclerosis lesion. Immune sensitization to neural antigens could develop within the systemic compartment ...
متن کاملP 51: The Role of T Helper 17 in Pathogenesis of Multiple Sclerosis
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) which causes demyelination of the nerve fibers. The etiology of this disease is not well understood but it is believed that T helpers play a central role in MS. Numerous findings support the view that Th17 cells play an essential role in pathogenesis of MS and IL-17 secreting T (Th17) cells have a role in infla...
متن کاملMultiple Sclerosis: Pathogenesis and Treatment
Multiple sclerosis (MS) is a chronic inflammatory autoimmune demyelinating disease of the central nervous system. It affects approximately 400,000 people in the United States and onset is usually during young adulthood. There are four clinical forms of MS, of which relapsing remitting type is the most common. As the etiology of MS is unknown, finding a cure will remain challenging. The main mec...
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ژورنال
عنوان ژورنال: Annales Academiae Medicae Silesiensis
سال: 2019
ISSN: 1734-025X
DOI: 10.18794/aams/83726